Synthesis and anti-inflammatory activities of some N-(pyridyl (phenyl) carbonylamino)-tert-butyl/phenyl-1,2,3,6-tetrahydropyridines.
نویسندگان
چکیده
منابع مشابه
synthesis and characterization of some macrocyclic schiff bases
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15 صفحه اولSynthesis of some new 2-(substituted-phenyl)-5-(N,N-diphenylaminomethyl)-1,3,4-oxadiazoles: a safer anti-inflammatory and analgesic agents.
A series of 2-(substituted-phenyl)-5-(N,N-diphenylaminomethyl)-1,3,4-oxadiazoles (3-15) were synthesized. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation actions. The percentage inhibition in edema at different time intervals indicated that compounds 8, 11, 12, 14 and 15 exhibited good anti-inflammatory potential. The results illustrate th...
متن کاملN-Phenyl-tert-butanesulfinamide
In the racemic title compound, C(10)H(15)NOS, the packing exhibits centrosymmetric pairs of mol-ecules linked by N-H⋯O=S hydrogen bonds in a head-to-tail fashion. The N-C(ar-yl) bond [1.4083 (12) Å] is considerably shorter than the N-C(alk-yl) bonds typically found in N-alkyl-alkanesulfinamides (1.470-1.530 Å).
متن کامل(S)-N-Phenyl-tert-butanesulfinamide
The asymmetric unit of the title compound, C(10)H(15)NOS, contains two independent mol-ecules with similar conformations. In the crystal, mol-ecules are linked in a head-to-tail fashion by N-H⋯O hydrogen bonds into chains running along the b axis. The absolute configuration was assigned on the basis of known chirality of the parent compound.
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Fibrates, as hypolipidemic drugs known as agonists of peroxisome proliferator-activated receptors, diminish inflammatory responses. Studies have shown that incorporation of a silicon atom into a drug structure improves its pharmacological potency, modifies its selectivity toward a given target, or changes its metabolic rate, in addition to increasing the lipophilicity of the compounds. A si...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1991
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.39.786